Originally developed by the Eli Lilly pharmaceutical company as an antidepressant, Dapoxetine pills are classified as a selective serotonin reuptake inhibitor (SSRI). The drug was designed to manipulate the neuronal reuptake of the hormone serotonin. However, clinical trials revealed the rapid absorption and swift elimination of dapoxetine HCl (the active ingredient in brands such as Priligy) by the body. This rapid therapeutic action made the pills more effective in treating a sexual disorder like premature ejaculation (PE) than in managing depressive symptoms.
In several countries, including Mexico and parts of Europe and Asia, these pills—often referred to as ‘last longer in bed pills’—are available for PE treatment through credible online pharmacies.
Function and Applications
Dapoxetine is used to prolong the time from an erection to ejaculation in men dealing with ejaculation-related sexual disorders. PE, a common sexual dysfunction affecting men, can be classified into:
- Acquired PE: Defined by the International Society for Sexual Medicine (ISSM) as a significant reduction in ejaculation latency time, acquired PE is often caused by psychological issues like anxiety or depression and can sometimes be reversed.
- Lifelong PE: This severe form of the disorder, usually incurable, occurs throughout all or nearly all sexual activities, starting from a person’s first sexual experiences.
Dapoxetine can manage symptoms of both acquired and lifelong PE, potentially improving control over ejaculation, satisfaction with sexual intercourse, and the time to reach sexual climax.
Finding Reliable Dapoxetine Suppliers Online
The best place to procure dapoxetine online is from a trustworthy, secure internet pharmacy. The use of online pharmacies simplifies the process of comparing the effects, prices, and potential risks of various medications. Additionally, these platforms offer access to user reviews and insights, making the decision-making process easier.
In some locations, dapoxetine can be purchased without a prescription. User reviews can provide insights into potential medication combinations, like using these PE pills alongside Viagra. Such combinations are safe and can be beneficial for individuals experiencing both PE and ED. Although dapoxetine isn’t available at physical pharmacies in the U.S, it can be procured through an online pharmacy. Using a reputable online pharmacy not only gives you access to this medication but also provides the opportunity to read user reviews and research various brands. However, it’s crucial to be aware of potential counterfeits when purchasing medication online. Always verify the pharmacy’s certification to ensure you’re receiving genuine medication.
Be sure to consult with a healthcare professional before starting dapoxetine or any other medication. This is especially important if you are taking other medications or have other health conditions, as these could potentially interact with dapoxetine.
Off-Label Use of Dapoxetine in the USA
Despite its lack of FDA approval in the U.S, dapoxetine is still used off-label to treat PE. Off-label drug use refers to when a drug is used for a purpose other than what it was approved for by the FDA. While it is legal for doctors to prescribe drugs off-label, it’s essential to have a thorough understanding of the potential risks and benefits of such use.
When used off-label, dapoxetine should only be taken under the supervision of a healthcare provider. They will be able to provide appropriate dosing information and monitor for potential side effects.
Mechanism of Action
As an SSRI, Dapoxetine’s effectiveness lies in altering serotonin activity in the brain through the following steps:
- Brain cells (neurons) communicate information through a network, processing it as signals. These signals are transmitted by neurotransmitters, one of which is serotonin.
- Known also as a hormone, serotonin regulates mood and emotions.
- For neurons to transmit signals, a small amount of neurotransmitter is released, facilitating message delivery. The released neurotransmitter is then reabsorbed (a process known as reuptake) for continued signal transmission.
- When feeling depressed, anxious, or experiencing PE symptoms, serotonin levels in your brain may be compromised or unevenly distributed.
- By preventing serotonin reuptake, dapoxetine increases the neurotransmitter’s availability, ensuring correct message delivery between brain cells.
With its specific targeting of serotonin (hence, being classified as a selective serotonin reuptake inhibitor), dapoxetine can effectively alleviate ejaculation problems, promoting longer-lasting sex.
Generic Priligy Dosage Guidelines
Typically, men use Dapoxetine 60 mg for PE treatment. However, the dosage may be reduced to 30 mg in case of adverse side effects or poor drug tolerance. Dosage should always follow indications as the drug can affect different people differently. Dapoxetine should be taken 1-3 hours before sexual activity, giving the body enough time to process the medication. The tablets are quickly absorbed by the body, classifying dapoxetine as a short-acting medication. The prescribed dosage of dapoxetine often begins at 60mg for treating PE. Depending on the individual’s tolerance and potential side effects, this dose may be reduced to 30mg. Dapoxetine’s effectiveness varies among individuals, and thus, there isn’t a universal dose. Irrespective of whether you consume dapoxetine 30mg or 60mg, it’s crucial to adhere to the instructions. Dapoxetine should be taken approximately one to three hours before engaging in sexual activity to allow ample time for digestion and absorption into the bloodstream.
As an SSRI, dapoxetine is absorbed quickly by the body, making it a short-acting medication. The initial half-life for dapoxetine is 1.31 hours and 1.42 hours for the 30mg and 60mg doses, respectively. This timeframe denotes the duration required for half the medication to be eliminated from the body. Pharmacokinetic research confirms that dapoxetine can be used alongside sildenafil, as they don’t interact harmfully. It’s common for men to suffer from both PE and erectile dysfunction, and using these medications concurrently may alleviate both issues effectively.
Side Effects
Like other SSRIs, dapoxetine has a similar side effect profile, including nausea, dizziness, headaches, diarrhea, dry mouth, and insomnia. The key to minimizing dapoxetine side effects lies in following the medication guidelines. However, if side effects persist, some measures can help alleviate them:
- Nausea: Natural compounds found in lemon can neutralize acids and stimulate salivation, relieving symptoms of nausea.
- Dry mouth: Drinking clear fluids like water or apple juice, alongside the use of lemon or lemon juice, can aid in soothing the discomfort from a dry mouth.
- Headaches: A simple solution for a headache can be applying a heating pad or a cold compress to the forehead.
- Diarrhea: Simultaneous consumption of salt and sugar can improve intestinal fluid absorption, offering relief from diarrhea. The World Health Organization recommends an oral rehydration solution containing eight level spoons of sugar and one level spoon of salt in a liter of water.
- Dizziness: Resting and sleep are the best ways to overcome dizziness.
- Insomnia: If sleeplessness persists, try consuming this medication during the daytime when it’s easier to stay active. If taking dapoxetine at night, consider natural sleep aids like chamomile tea.